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CYP1A2, CYP2B6, CYP2C9, CYP2C19 and CYP3A4/5 are implicated as cytochrome P450 enzymes involved in the metabolism of clopidogrel. However, the relative importance of the individual enzymes and which part of the reaction they are involved in are controversial, as discussed in the literature.
Directions. This medicine should be taken with or without food once daily.
Elimination. Following an oral dose of 14C-labeled clopidogrel in humans, approximately 50% of total radioactivity was excreted in urine and approximately 46% in feces over the 5 days post-dosing. After a single, oral dose of 75 mg, clopidogrel has a half-life of approximately 6 hours.
BRAND NAME: Plavix. DRUG CLASS AND MECHANISM: Clopidogrel bisulfate is an anti-platelet drug, that is, a drug that inhibits the ability of platelets to clump together as part of a blood clot.























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